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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
21.82
Human Site:
S749
Identified Species:
40
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S749
L
N
M
R
Q
S
L
S
T
F
S
S
E
N
P
Chimpanzee
Pan troglodytes
XP_509099
871
93967
S760
L
N
M
R
Q
S
L
S
T
F
S
S
E
N
P
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S779
L
N
M
R
Q
S
L
S
T
F
S
S
E
N
P
Dog
Lupus familis
XP_857182
860
93116
S749
L
N
M
R
Q
S
R
S
T
F
S
S
E
N
P
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
N776
Q
R
W
P
Q
G
P
N
M
R
Q
S
L
S
T
Rat
Rattus norvegicus
Q63796
888
96289
S780
Q
G
P
N
M
R
Q
S
L
S
T
F
S
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
S835
I
S
S
C
Q
S
Y
S
T
F
S
S
E
N
F
Frog
Xenopus laevis
A7J1T0
961
107551
S845
M
S
T
C
Q
S
Y
S
T
F
S
S
E
N
F
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
F737
K
C
Q
S
V
S
T
F
S
S
E
N
L
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
S981
D
L
Y
T
S
S
A
S
I
S
F
A
T
Y
R
Honey Bee
Apis mellifera
XP_397605
895
101116
A767
L
C
D
R
E
D
D
A
C
E
E
S
W
S
D
Nematode Worm
Caenorhab. elegans
O01700
928
103465
V796
T
Y
S
N
P
C
H
V
E
L
V
D
E
E
N
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
P820
S
D
N
E
E
A
A
P
D
H
S
S
D
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
100
100
93.3
N.A.
13.3
6.6
N.A.
N.A.
60
60
6.6
N.A.
13.3
20
6.6
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
26.6
20
N.A.
N.A.
73.3
73.3
26.6
N.A.
20
40
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
16
8
0
0
0
8
0
0
0
% A
% Cys:
0
16
0
16
0
8
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
8
8
0
0
8
8
0
8
0
0
8
8
0
16
% D
% Glu:
0
0
0
8
16
0
0
0
8
8
16
0
54
16
8
% E
% Phe:
0
0
0
0
0
0
0
8
0
47
8
8
0
0
16
% F
% Gly:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
39
8
0
0
0
0
24
0
8
8
0
0
16
0
0
% L
% Met:
8
0
31
0
8
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
31
8
16
0
0
0
8
0
0
0
8
0
47
8
% N
% Pro:
0
0
8
8
8
0
8
8
0
0
0
0
0
0
31
% P
% Gln:
16
0
8
0
54
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
0
8
0
39
0
8
8
0
0
8
0
0
0
0
8
% R
% Ser:
8
16
16
8
8
62
0
62
8
24
54
70
8
31
0
% S
% Thr:
8
0
8
8
0
0
8
0
47
0
8
0
8
0
8
% T
% Val:
0
0
0
0
8
0
0
8
0
0
8
0
0
0
8
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
8
8
0
0
0
16
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _